It has been previously reported in multiple studies that individuals with Rheumatoid Arthritis (RA) – an autoimmunedisease that causes inflammation and damage to joints – have specific alterations in their gut bacteria. And now a new study is showing how manipulation of the gut bacteria may provide a novel approach to therapy.
In the study, a group of RA mice were treated with a human-derived bacterium called Prevotella histicola. After 8 weeks, P. histicola led to decreased symptom frequency and severity, and fewer signs of inflammation associated with RA as compared to controls.
Suppression of RA was also demonstrated by an observed increase in the anti-inflammatory messenger IL-10 and an increase in anti-autoimmune T regulatory cells.
Interestingly, the study also looked at the intestinal lining of the RA mice and found that those treated with P. histicola had lower gut permeability and increased expression of tight junction proteins (zonulin and occludin). This suggests that the anti-RA effects of P. histicola are mediated via reducing leaky gut syndrome, in which bacteria and food leak across the intestinal lining and aggravate the immune system.
Relieving arthritis by manipulating the gut bacteria is a new area of research that may provide additional therapeutic options for people living with RA.
Read all about it: https://genomemedicine.biomedcentral.com/…/s13073-016-0299-7 http://onlinelibrary.wiley.com/d…/10.1002/art.39785/abstract